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. 2020 Sep 25;9(10):2167. doi: 10.3390/cells9102167

Figure 3.

Figure 3

Effects of Rho GTPases on steps of cancer initiation and metastatic progression. Although some studies have shown conflicting data (specifically in the case of Rho), the literature generally agrees that increased activation of Rho GTPases results in breast cancer initiation, metastatic progression, chemoresistance and radioresistance.