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Proposed in vivo trafficking of mesoporous silica nanoparticle (MSN) to the tumor microenvironment. (a) MSN administered intravenously was rapidly internalized by systemic macrophages. (b) Macrophages are highly dynamic and interactive, with intercellular connections, known as tunneling nanotubes (TNT), enabling direct cell-to-cell transfer of MSN to neighboring or distant cells. (c) Proposed movement of MSN to the tumor microenvironment.
