Table 2.

The Amsterdam criteria I, II and the Revised Bethesda Guidelines [7,13,54].

Amsterdam Criteria I:

At least three relatives with histologically verified colorectal cancer and one of which is a first-degree relative of the other two *, At least two successive generations affected, At least one of the relatives with colorectal cancer diagnosed at < 50 years of age.

Amsterdam Criteria II:

At least three relatives with histologically verified HNPCC-associated cancer (colorectal cancer, endometrial, stomach, ovary, ureter/renal pelvis, brain, small bowel, hepatobiliary tract and skin (sebaceous tumors) and one of which is a first-degree relative of the other two *, At least two successive generations affected, At least one of the HNPCC-associated cancers should be diagnosed at < 50 years of age.

Revised Bethesda Guidelines:

CRC diagnosed at < 50 years of age, Presence of synchronous or metachronous CRC or other LS-associated tumors ** regardless of age, Colorectal cancer with MSI-H histology diagnosed in a patient < 60 years of age, Colorectal cancer or LS-associated * tumor diagnosed under the age of 50 years in at least one first-degree relative, Colorectal cancer or LS-associated tumor ** diagnosed at any age in two first- or second-degree relatives

* Familial adenomatous polyposis should be excluded. ** LS-associated tumors include a tumor of the colorectum, endometrium, ovary, pancreas, stomach, renal pelvis, ureter, brain, biliary tract, small bowel, sebaceous glands, and keratoacanthomas.