Table 4.
Perinatal outcome in the studied groups.
| Parameter | 1993–2000 I n = 91 |
2001–2005 II n = 83 |
2006–2018 III n = 276 |
All n = 450 |
p-Value ** |
|---|---|---|---|---|---|
| Delivery (without miscarriages), week (SD) * | 36.5 (2.5) | 36.4 (3.0) | 37.1 (2.1) | 36.8 (2.4) | p = 0.06 |
| Number of miscarriages ≤ 12 weeks, n (%) ** | 9 (9.9) | 7 (8.4) | 21 (7.6) | 37 (8.2) | Gr.I vs. Gr.II p = 0.74 Gr.Ivs.Gr.III p = 0.50 Gr.II vs. Gr.III p = 0.80 |
| Number of deliveries, n (%) **,^ | 82 (90.1) | 75 (90.4) | 231 (83.8) | 388 (86.2) | Gr.I vs. Gr.II p = 0.91 Gr.I vs. Gr.III p = 0.15 Gr.II vs. Gr.III p = 0.15 |
| Number of premature deliveries (22–36 weeks), n (%) **,^ |
34 (41.5) | 25 (33.3) | 59 (25.5) | 118 (30.4) | Gr.I vs. Gr.II p = 0.31 Gr.I vs. Gr.III p < 0.01 Gr.II vs. Gr.III p = 0.1 |
| Number of deliveries ≤ 32 weeks, n (%) **,^ | 4 (5.2) | 8 (8.1) | 7 (2.7) | 19 (4.2) | Gr.I vs. Gr.II p < 0.02 |
| Number of deliveries > 36 weeks, n (%) **,^ | 48 (58.5) | 50 (66.7) | 172 (74.5) | 270 (69.6) | Gr.Ivs.Gr.II p=0.32 Gr.I vs. Gr. III p = 0.11 Gr.II vs. Gr.III p = 0.73 |
| Number of spontaneous deliveries, n (%) **,^ | 2 (2.4) | 10 (13.3) | 35 (15.2) | 46 (11.9) | Gr.I vs. Gr.II p < 00001 Gr.I vs. Gr.III p < 0.001 Gr.II vs. Gr.III p = 0.88 |
| Number of cesarean sections, n (%) **,^ | 80 (97.6) | 65 (86.7) | 196 (71.0) | 342 (88.1) | |
| Elective, n (%) | 54 (67.5) | 42 (63.6) | 135 (68.9) | 231 (67.5) | Gr.I. vs. Gr.II p = 0.71 Gr.I vs. Gr. III p < 0.01 Gr.II vs. Gr.III p = 0.52 |
| Emergency (n, %) | 22 (27.5) | 11 (16.7) | 22 (11.2) | 55 (16.1) | |
| Mean newborn weight > 32 weeks, g (IQR) * | 2950 (2420–3240) |
3320 (2920–3700) |
3290 (2940–3700) |
3220 (2800–3640) |
p < 0.0001 |
| Newborns above 36 weeks ≥ 4000 g, n (%) ** | 3 (1.0) | 6 (2.0) | 34 (11.2) | 43 (14.1) | Gr.I vs. Gr.II p = 0.24 Gr.I vs. Gr.III p < 0.01 Gr.II vs. Gr. III p = 0.13 |
| Newborns above 36 weeks ≤ 2500 g, n (%) ** | 11 (3.6) | 3 (1.0) | 7 (2.3) | 21 (6.9) | Gr.I vs. Gr.II p < 0.02 Gr.I vs. Gr.III p < 0.0005 Gr.II vs. Gr.III p < 0.0001 |
| SGA, n (%) ** | 20 (24.4) | 9 (12.0) | 20 (8.7) | 49 (12.6) | Gr.I vs. Gr.II p < 0.03 ^ Gr.I vs. Gr.III p < 0.002 ^ Gr.II vs. Gr.III p = 0.40 ^ |
| LGA, n (%) ** | 5 (6.1) | 16 (21.3) | 50 (21.6) | 71 (18.3) | Gr.I vs. Gr.II p < 0.01 ^ Gr.I vs. Gr.III p < 0.001 ^ Gr.II vs. Gr.III p = 0.95 |
| APGAR score 1 min ≤ 7, n (%) ** | 45 (48.9) | 23 (27.4) | 32 (11.3) | 100 (27.0) | Gr.I vs. Gr.II p < 0.03 Gr.I vs. Gr.III p < 0.0001 Gr.II vs. Gr.III p < 0.005 |
| Umbilical artery pH, (IQR) * | 7.21 (7.18–7.28) | 7.26 (7.20–7.30) | 7.24 (7.18–7.30) | 7.24 (7.18–7.29) | p = 0.18 |
| Umbilical artery pH ≤ 7.15, n (%) ** | 12 (13.0) | 8 (9.5) | 27 (10.5) | 47 (10.2) | Gr.I vs. Gr.II p = 0.58 Gr.I vs. Gr.III p = 0.44 Gr.II vs. Gr.III p = 0.90 |
| Umbilical artery pH < 7.05, n (%) ** | 2 (2.2) | 3 (3.6) | 10 (3.9) | 15 (3.3) | Gr.I vs. Gr.II p < 0.03 Gr.I vs. Gr.III p < 0.0001 Gr.II vs. Gr. III p < 0.005 |
| Number of malformations, n (%) ** | 3 (3.3) | 2 (2.7) | 9 (3.9) | 14 (3.6) | Gr.I vs. Gr.II p = 0.72 Gr.I vs. Gr.III p = 0.9 Gr.II vs. Gr.III p = 0.62 |
| Perinatal death until the 7th day, n (%) ** | 3 (3.3) | 2 (2.7) | 0 | 5 (1.1) | Gr.I vs. Gr.II p = 0.72 Gr.I vs. Gr.III p < 0.005 Gr.II vs. Gr.III p < 0.02 |
* ANOVA rang Kruskal-Wallis test; ** Chi 2 test; ^ number of patients whose data were available; SD (standard deviation); IQR (interquartile range); LGA (large for gestational age).