Table 2.

Summary statistics of the Immunogradient and intratumoral immune cell density indicators in patients grouped by tumor microsatellite instability status.

Immunogradient and Intratumoral Cell Density (Cells/mm2) Indicators	MSS CRC, n = 48			MSI CRC, n = 39
	Mean	Median	sd	Mean	Median	sd	p-Value *
CD8_CM	−0.35	−0.35	0.17	−0.20	−0.18	0.21	0.0006 *
CD8_d_S	193.78	147.06	147.73	370.76	294.91	404.69	0.0024 *
CD8_d_TE	141.82	90.03	128.49	339.94	208.15	400.52	0.0004 *
CD8_d_T	76.47	49.24	92.49	262.40	140.22	342.64	0.0001 *
INT_CD8	65.37	37.59	81.99	238.90	133.46	311.26	<0.0001 *
CD20_CM	−0.49	−0.54	0.23	−0.59	−0.63	0.14	0.0141 *
CD20_d_S	54.26	32.81	68.44	71.37	36.78	83.35	0.3650
CD20_d_TE	31.61	14.01	59.39	30.56	18.93	33.44	0.7857
CD20_d_T	12.20	4.66	30.68	5.40	3.87	6.12	0.0899
INT_CD20	13.75	4.19	31.21	9.70	5.88	12.90	0.6003
CD68_CM	−0.26	−0.28	0.14	−0.11	−0.08	0.14	<0.0001 *
CD68_d_S	173.95	158.15	118.19	182.45	173.88	104.31	0.5616
CD68_d_TE	145.14	120.25	99.73	190.06	175.17	106.06	0.0281 *
CD68_d_T	72.49	55.29	73.41	126.52	100.39	82.40	<0.0001 *
INT_CD68	60.04	48.90	55.89	112.15	95.33	71.48	<0.0001 *

CD8_d, CD20_d and CD68_d indicate mean density for each biomarker, respectively; densities are summarized over hexagons in the stroma aspect (S), tumor edge (TE) and tumor aspect (T) of the IZ; INT—mean intratumoral density; CM—Center of Mass implicitly by mean cell density in ranks; sd—standard deviation of indicator. * p-value < 0.05 is considered significant.