Table 1.

Synthesis of 2-(3-nitro-1,2,4-triazol-1-yl)pyrimidines 1a-s.

Entry	Compound	Product	Ratio 1:2	Isolated Yield of 1 (%)
1	1a		4.6:1	65
2	1b		2.5:1	48
3	1c		3.2:1	61
4	1d		4:1	68
5	1e		11.2:1 a	45
6	1f		4.6:1	35
7	1g		2.2:1	46
8	1h		3.5:1	38
9	1i		22:1	66
10	1j		3.5:1	39
11	1k		1.4:1	32
12	1l		1.2:1	28
13	1m		1.6:1 a	35
14	1n		3.5:1	47
15	1o		2.4:1	43
16	1p		7.2:1	66
17	1q		4:1	44
18	1r		- b	61
19	1s		- b	19

^a Reactions were performed at 100 °C in DMSO over 24–48 h. ^b No regioisomer was formed.