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The figure shows the structures aligned in PyMOL of transmissible gastroenteritis virus (TGEV) PLpro (Protein Data Bank Identifier (PDB ID): 3MP2; green), Middle East respiratory syndrome CoV (MERS-CoV) PLpro (PDB: 4P16; yellow), severe acute respiratory syndrome coronavirus (SARS-CoV) PLpro (PDB: 2FE8; blue), and SARS-CoV-2 PLpro (PDB: 6W9C; pink); UBL—ubiquitin-like domain.
