Figure 4.

Cellular and non-cellular components of PDAC and adjacent tissue. Left: diagram of PDAC and adjacent tissue components. Right: key to cell identities. Cancer cells and tumor-associated stromal cells (left column) are found in association with adjacent normal epithelial and stromal pancreatic cells (right column). Normal cells are surrounded by tissue ECM (light grey). PDAC cancer and stromal cells are surrounded by the tumor ECM (dark grey). Hypoxia and low pH areas are found inside tumors (light pink). Some normal cells (green shade) can be found inside both tumor and adjacent tumor stroma. Magenta: Tumor microenvironment comprises non-cancer cells, tumor ECM and environmental conditions.