Figure 2.

Gene ontology analysis of proteins commonly expressed in C. albicans biofilms. Analysis of overlapping differentially expressed proteins under bacterial stimulations revealed 164 proteins to be consistently downregulated and three proteins to be consistently upregulated. Biological processes, molecular functions, and cellular components were found to be significantly altered in C. albicans biofilms under stimulations of nine oral bacteria species; A. actinomycetemcomitans, A. naeslundii, F. nucleatum, E. faecalis, P. gingivalis, S. mutans, S. sanguinis, S. mitis, and S. sobrinus bacteria (p-value < 0.05). The protein expression levels were represented in p-value using different colors: yellow (least significant) to orange (most significant). The white circle represents cellular component, a distinct aspect of how gene functions can be described.