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. 2020 Oct 12;9(10):2276. doi: 10.3390/cells9102276

Figure 5.

Figure 5

(a) Interaction of the C-domain (shown in yellow box) of IGF-II (grey) and IGF-I (black) with IGF-1R (PDB: 6VWI and 6PYH, respectively). Domains of IGF-1R coloured as in Figure 3. Residues of the CR and L1 domain engage with residue Tyr31 of IGF-I. Contact is also made between C-domain residues Arg36 and Arg37 of IGF-I and the L2 domain. There is no equivalent C-domain residue in IGF-II. (b) Site 2 contacts involve residues Glu12 of IGF-II and Glu9 IGF-I which contact FnIII-1 domain residue Arg483 (dark green represents the IGF-1:IGF-1R structure and light green the IGF-II:IGF-1R structure). (a,b) coloured as in Figure 3.