Table 1.
EV proteins rapidly synthesized by A549 lung cancer cells in response to hypoxia.
| Protein Names (Gene Symbols) |
A549 Cells (Nx) | A549 EVs (Nx) | A549 Cells (Hx) | A549 EVs (Hx) | Hypoxia Inducible Gene | ||||
|---|---|---|---|---|---|---|---|---|---|
| H/L | emPAI | H/L | emPAI | H/L | emPAI | H/L | emPAI | ||
| Angiopoietin-Related Protein 4 (ANGPTL4) | - | - | - | - | - | 0.122 | 100 | 0.413 | Yes [21] |
| Neurensin 2 (NRSN2) | - | - | - | - | - | - | 100 | 0.233 | - |
| WNT1-Inducible-Signaling Pathway Protein 2 (WISP2) | - | - | - | - | - | - | 100 | 0.212 | Yes [22] |
| Isoform 2 of CD70 Antigen (CD70) | - | - | - | - | - | - | 100 | 0.212 | Yes [23] |
| Sushi-Repeat-Containing Protein, X Chromosome (SRPX) | - | - | - | - | - | - | 100 | 0.179 | - |
| Golgi Membrane Protein 1 (GOLM1) | 100 | 0.995 | - | - | 58.319 | 0.995 | 100 | 0.166 | - |
| Stanniocalcin 1 (STC1) | - | - | - | - | - | 0.145 | 100 | 0.145 | Yes [24] |
| Transmembrane Protein 59 (TMEM59) | - | - | - | - | - | - | 100 | 0.129 | - |
| Galactosylgalactosylxylosylprotein 3-Beta-Glucuronosyltransferase 2 (B3GAT2) | - | - | - | - | - | - | 100 | 0.11 | - |
| Isoform 3 of Tyrosine-Protein Kinase Lck (LCK) | - | - | - | - | - | - | 100 | 0.08 | Yes [25] |
| Chromosome 1 Open Reading Frame 112 (C1orf112) | 1.368 | 0.061 | - | - | - | - | 100 | 0.061 | - |
| Isoform 2 of Alpha,6-Mannosylglycoprotein 6-Beta-N-Acetylglucosaminyltransferase B (MGAT5B) | - | - | - | - | - | - | 100 | 0.047 | - |
| Laminin Subunit Beta 2 (LAMB2) | 100 | 0.021 | - | - | 51.099 | 0.043 | 34.822 | 0.065 | - |
| Transferrin (TF) | - | - | - | - | - | - | 33.341 | 0.166 | Yes [26] |
| Carboxypeptidase (CTSA) | 3.04 | 0.096 | 1.641 | 0.905 | 2.4865 | 0.318 | 21.021 | 0.738 | Yes [3] |
| Fibrinogen-Like Protein 1 (FGL1) | - | - | - | - | - | - | 14.448 | 0.136 | - |
| Tyrosine-Protein Kinase Receptor (SDC4-ROS1_S4;R32) | - | - | - | - | 100 | 0.061 | 7.664 | 0.061 | - |
| Fructose-Bisphosphate Aldolase (ALDOC) | - | - | 0.542 | 1.593 | - | - | 6.13 | 4.736 | Yes [27] |
| Insulin-Like Growth Factor-Binding Protein 3 (IGFBP3) | - | - | - | - | 37.926 | 0.931 | 6.039 | 0.551 | Yes [28] |
| MucinB (MUC5B) | - | - | - | - | - | - | 3.878 | 0.746 | - |
| Pleckstrin Homology Domain-Containing Family B Member 2 (PLEKHB2) | - | - | - | - | - | - | 3.853 | 0.116 | - |
| Eukaryotic Initiation Factor 4A-III (EIF4A3) | 1.6715 | 13.454 | - | - | 1.5165 | 19.893 | 2.378 | 0.318 | - |
| Hepatocyte Growth Factor Receptor (MET) | 13.464 | 0.415 | - | - | 1.06 | 0.658 | 2.265 | 0.032 | Yes [29] |
| Isoform 2 Procollagen-Lysine,2-Oxoglutarate 5-Dioxygenase 2 (PLOD2) | 1.9435 | 3.885 | 0.586 | 0.848 | 10.655 | 7.149 | 2.227 | 3.642 | Yes [30] |
| Ferritin Heavy Chain (FTH1) | - | 0.359 | 1.16 | 12.594 | 8.775 | 0.166 | 2.177 | 20.544 | Yes [31] |