Figure 6.

Lupeol treatment enhanced memory impairments in the Aβ-mouse model of AD. To examine the memory function of the experimental mice, the MWM and Y-maze were performed (n = 15 mice/group). (a) Average escape latency time for experimental mice to reach the hidden platform. (From day 1 to 4 days). (b) The average number of crossing in the MWM in the hidden platform during the probe test. (c) Time in the quadrant was previously the hidden platform was placed during the training session. (d) Spontaneous alteration behavior % of the mice during the Y-maze test. The data are shown as a mean ± S.E.M. * Significantly different from normal saline-treated mice and # significantly different from Aβ-injected mice, respectively; * p 0.05, # p 0.05. Cont: Control, Aβ: Amyloid beta, Lup: Lupeol.