Table 1. Characteristics of included studies.
| Study/year | Country | Study design | Sample size | Age (years) | Male (%) | BMI (kg/m2) | mMRC | FEV1, % predicted | Pseudomonas aeruginosa (%) | Number of affected lobes | Exacerbations (previous year) | Follow-up time (years) | Mortality (%) | Hospitalization (%) | Scales |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Martínez-García/2014a | Spain | R | 397 | 59.20 ± 17.40 | 44.30 | 26.10 ± 4.28 | 1.57 ± 1.17 | 68.50 ± 25.60 | 31.80 | 2.45 ± 1.12 | 2.47 ± 2.10 | 5 | 19.90 | NA | FACED |
| Martínez-García/2014b | Spain | R | 422 | 58.30 ± 17.70 | 42.60 | 25.35 ± 4.98 | 1.50 ± 1.15 | 68.70 (26.30) | 31.80 | 2.59 ± 1.17 | 2.57 ± 2.30 | 5 | 17.80 | NA | FACED |
| Chalmers/2014 | U.K. | P | 608 | 67 (58–75) | 39.97 | NA | 2 (1, 3) | 72.60 ± 25.00 | 11.51 | 3.0 ± 1.6 | 1.7 ± 2.0 | 4 | 10.20 | 0.08 | BSI |
| Ellis/2016 | U.K. | R | 74 | 52.50 ± 12.40 | NA | 23.40 ± 3.90 | 2.10 ± 0.90 | 68.80 ± 27.70 | 22.00 | 3.40 ± 1.50 | 4.40 ± 4.40 | 18.8 | 35 | NA | BS FACEDI |
| McDonnell/2016a | Dundee, U.K. | P | 494 | 65.30 ± 12.90 | 39.30 | 25.90 ± 5.20 | 2.30 ± 1.10 | 71.60 ± 24.7 | 12.80 | 4.40 ± 3.00 | 2.10 ± 2.60 | 4 | 8.5 | 0.05 | BSI FACED |
| McDonnell/2016b | Newcastle, England | P | 126 | 59.10 ± 14.50 | 40.5 | 26.20 ± 5.10 | 2.50 ± 1.10 | 64.00 ± 26.90 | 10.30 | 2.80 ± 1.40 | 3.40 ± 1.70 | 4 | 12.7 | 0.11 | BSI FACED |
| McDonnell/2016c | Belgium | P | 190 | 66.40 ± 16.00 | 49 | 23.90 ± 4.30 | 2.30 ± 1.20 | 69.30 ± 25.30 | 8.40 | 4.50 ± 1.30 | 1.90 ± 2.10 | 5 | 23.16 | 0.06 | BSI FACED |
| McDonnell/2016d | Monza, Italy | P | 250 | 65.10 ± 12.20 | 41.2 | 23.70 ± 4.40 | 2.00 ± 1.30 | 79.20 ± 27.50 | 21.60 | 5.50 ± 2.70 | 1.90 ± 2.00 | 4 | 5.60 | 0.09 | BSI FACED |
| McDonnell/2016e | Galway, Ireland | P | 280 | 60.50 ± 14.60 | 32.9 | 27.10 ± 5.60 | 2.00 ± 1.00 | 80.30 ± 25.90 | 13.90 | 3.40 ± 3.00 | 2.90 ± 1.30 | 5 | 15.71 | 0.03 | BSI FACED |
| McDonnell/2016f | Athens, Greece | P | 159 | 59.30 ± 16.20 | 36 | 24.60 ± 3.40 | 2.40 ± 1.50 | 70.10 ± 24.90 | 36.50 | 4.80 ± 2.50 | 2.40 ± 1.50 | 5 | 5.66 | 0.04 | BSI FACED |
| McDonnell/2016g | Vojvodina, Serbia | P | 113 | 62.00 ± 13.00 | 29.2 | 25.10 ± 4.90 | 2.50 ± 1.40 | 64.80 ± 26.20 | 1.00 | 4.70 ± 2.40 | 1.00 ± 1.25 | 5 | 17.70 | 0.02 | BSI FACED |
| Athanazio/2017 | Latin America | R | 651 | 48.20 ± 16.00 | 32.9 | 22.40 ± 11.50 | 1.52 ± 1.00 | 54.70 ± 22.10 | 39.80 | 3.30 ± 1.50 | 1.12 ± 1.40 | 5 | 14.60 | 0.30 | FACED |
| Sim/2017 | Singapore | P | 96 | 70 (59.3–77) | 37.5 | 19.20 (15.70–23.10) | NA | 47.00 (37.00–63.30) | NA | NA | NA | 5 | 42.70 | NA | BSI FACED |
| Wang/2018 | China | R | 596 | 54.81 ± 13.71 | 56.88 | NA | NA | NA | NA | NA | NA | 5 | 7.05 | 0.06 | BSI FACED |
| Rosales-Mayor/2017 | Spain | P | 182 | 68.00 ± 14.60 | 40.10 | 25.60 ± 4.60 | 1.30 ± 1.10 | 70.30 ± 21.80 | 20.90 | 3.20 ± 1.60 | 1.80 ± 1.80 | 1 | NA | 0.27 | BSI FACED |
| Costa/2018 | Portugal | R | 40 | 65.90 ± 14.10 | 45.00 | 26.20 ± 5.60 | 2 | 63.40 ± 22.10 | 12.50 | 3.60 ± 1.40 | 1.20 ± 1.50 | NA | NA | NA | BSI FACED |
| Minov/2015 | Macedonia | R | 37 | 63.40 ± 8.10 | 80.00 | 24.30 ± 3.70 | 1.83 ± 0.63 | 57.60 ± 8.70 | 8.10 | 2. 25 ± 0.78 | 2.12 ± 0.54 | NA | NA | NA | BSI FACED |
Data are presented as mean ± SD or median (interquartile range). Abbreviations: NA, not available; P, prospective; R, retrospective.
a, b, c etc means different cohorts in one study.