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. 2020 Oct 30;40(10):BSR20202856. doi: 10.1042/BSR20202856

Figure 1. The Kyn pathway of tryptophan degradation.

Figure 1

Adapted from Figure 1 in [26] [Badawy, A.A.-B. (2017). Kynurenine pathway of tryptophan metabolism: regulatory and functional aspects. Int. J. Tryptophan Res. 10, 1-20, doi: 10.1177/1178646917691938]. Colours indicate a proinflammatory (red), anti-inflammatory (green), a mixed or partially proinflammatory (amber) or a normal metabolite (yellow). Abbreviations: 3-HAAO, 3-hydroxyanthranilic acid 3,4-dioxygenase; KAT, Kyn aminotransferase; KMO, Kyn monooxygenase; N′FK, N′-formylkynurenine; TDO, tryptophan 2,3-dioxygenase.