Table 2.
MICs (mg.mL−1) of ethyl acetate sub-extracts of chicory hairy roots (EtOAc HR1, ethyl acetate sub-extract of not elicitated hairy roots; EtOAc HR2, ethyl acetate sub-extract of elicitated hairy roots) and two pure compounds (CQA, 3-caffeoylquinic acid; di-CQA; 3,5-dicaffeoylquinic acid) against some human pathogenic bacteria and fungi. MICs (in µg·mL−1) of some antibiotics (GEN, gentamicin; VAN, vancomycin; AMX, amoxicillin) and antifungal agents (AMB, amphotericin B; FLC, fluconazole; SER, sertaconazole) against the same pathogens panel.
| Bacterial and Fungal Pathogen Strains | MIC (mg mL−1) | MIC (µg mL−1) | |||||
|---|---|---|---|---|---|---|---|
| EtOAc HR1 |
EtOAc HR2 |
CQA | di-CQA | GEN | VAN | AMX | |
| Gram positive | |||||||
| Corynebacterium striatum T40A3 | 0.313 | 0.313 | 0.156 | 0.156 | 0.03 | 1 | 0.25 |
| Enterococcus faecalis C159-6 | NA | 1.25 | 0.625 | 0.625 | 4 | 0.5 | 64 |
| Enterococcus sp. 8153 | NA | NA | NA | NA | 2 | 4 | 2 |
| Staphylococcus aureus 8146 | 0.625 | 0.625 | 0.625 | 0.313 | 0.5 | 2 | 4 |
| Staphylococcus aureus 8241 | 0.625 | 0.313 | 0.313 | 0.313 | 0.5 | 2 | 16 |
| Staphylococcus aureus ATCC 6538 | 0.625 | 0.625 | 0.313 | 0.313 | 0.25 | 2 | 0.125 |
| Staphylococcus aureus T28-1 | 0.625 | 0.625 | 0.313 | 0.156 | 0.5 | 2 | 16 |
| Staphylococcus aureus T17-4 | 0.625 | 0.313 | 0.313 | 0.313 | 0.5 | 2 | 1 |
| Staphylococcus warneri T12A12 | 0.313 | 0.313 | 0.156 | 0.156 | 0.06 | 2 | 1 |
| Staphylococcus warneri T26A1 | 0.313 | 0.313 | 0.156 | 0.156 | 0.06 | 2 | 0.25 |
| Staphylococcus epidermidis T46A1 | 0.313 | 0.156 | 0.156 | 0.156 | 0.06 | 2 | 0.5 |
| Staphylococcus epidermidis T19A1 | 0.313 | 0.156 | 0.156 | 0.156 | 32 | 2 | 8 |
| Staphylococcus epidermidis T21A5 | 0.156 | 0.156 | 0.156 | 0.156 | 0.06 | 2 | 16 |
| Staphylococcus pettenkoferi T47A6 | 0.156 | 0.156 | 0.156 | 0.156 | 0.06 | 2 | 0.25 |
| Streptococcus agalactiae T53C9 | 0.625 | 0.313 | 0.313 | 0.156 | 1 | 0.5 | 0.03 |
| Streptococcus pyogenes 16138 | 0.313 | 0.156 | 0.313 | 0.313 | 0.125 | 0.25 | 0.03 |
| Gram negative | |||||||
| Citrobacter freundii 11041 | NA | NA | NA | 1.25 | 0.25 | >64 | 2 |
| Enterobacter aerogenes 9004 | NA | NA | NA | NA | 0.5 | >64 | >64 |
| Escherichia coli T20A1 | NA | NA | NA | NA | 0.25 | >64 | >64 |
| Escherichia coli 8138 | NA | NA | NA | NA | 0.5 | >64 | >64 |
| Escherichia coli 8157 | NA | NA | NA | NA | 0.5 | >64 | >64 |
| Escherichia coli ATCC 25922 | NA | NA | NA | NA | 0.5 | >64 | 16 |
| Klebsiella pneumoniae 11016 | NA | NA | NA | NA | 0.25 | >64 | >64 |
| Klebsiella pneumoniae 10270 | NA | NA | NA | NA | 8 | >64 | >64 |
| Proteus mirabilis 11060 | 1.25 | 0.625 | 0.625 | 0.625 | 0.5 | >64 | 2 |
| Proteus mirabilis T28-3 | 0.625 | 0.625 | 1.25 | 0.313 | 0.5 | >64 | 1 |
| Pseudomonas aeruginosa 8131 | 0.313 | 0.625 | 0.625 | 0.625 | 1 | >64 | >64 |
| Pseudomonas aeruginosa ATCC 27583 | 0.156 | 0.313 | 0.313 | 0.156 | 2 | >64 | >64 |
| Pseudomonas aeruginosa 8129 | 0.313 | 0.313 | 0.313 | 0.313 | 0.03 | >64 | >64 |
| Salmonella sp. 11033 | NA | NA | NA | NA | 0.25 | >64 | 2 |
| Fungi | AMB | FLC | SER | ||||
| Candida albicans 10286 | NA | 0.625 | NA | 1.25 | 4 | 32 | >64 |
| Candida albicans ATCC 10231 | 0.156 | 0.156 | 0.078 | 0.078 | 0.5 | 8 | 64 |
NA, non-active (MIC value ≥ 1.25 mg.mL−1).