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. 2020 Oct 11;18(10):511. doi: 10.3390/md18100511

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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SCC-promoted growth factors secretion in skin wounds. The sections of skin wound from C57BL/6J mice at day 5 and day 10 were stained with (A) vascular endothelial growth factor (VEGF), (B) basic fibroblast growth factor (bFGF), (C) transforming growth factor-β (TGF-β), and (D) connective tissue growth factor (CTGF) (brown color) by immunohistochemistry. The relative expression of growth factors was counted in at least five different fields in each mouse and quantified by Image J. Mean values within each column with different labels (a–f) are significantly different (p < 0.05) according to one-way ANOVA analysis of variance and Duncan’s multiple range test.