Table 8.

Comparison of the composition of gut microbiota [M(P25,P75)] in the two groups.

Phylum	Genus	Study Period	a-LCD (n =22)	LFD (n =23)	Z	p(adj. val.)
Firmicutes		Baseline	0.389 (0.283,0.729)	0.544 (0.455,0.671)	−1.317	0.188 (0.194)
		Third month	0.580 (0.371,0.672)	0.684 (0.561,0.778)	−2.317	0.021 * (0.026)
		Z	−1.282	−2.281
		p(adj. val.)	0.200 (0.213)	0.023 * (0.038)
	Roseburia	Baseline	0.002 (0.000,0.005)	0.009 (0.005,0.024)	−1.892	<0.01 ** (<0.01)
		Third month	0.005 (0.000,0.006)	0.000 (0.000,0.001)	−2.626	<0.01 ** (<0.01)
		Z	−2.193	−4.075
		p(adj. val.)	0.028 * (0.021)	<0.01 ** (<0.01)
	Eubacterium	Baseline	0.008 (0.004,0.0220)	0.037 (0.018,0.070)	−3.747	<0.01 ** (<0.01)
		Third month	0.026 (0.004,0.057)	0.042 (0.024,0.099)	−2.082	0.037 * (0.073)
		Z	−2.678	−1.734
		p(adj. val.)	<0.01 ** (0.013)	0.083 (0.052)
	Ruminococcus	Baseline	0.017 (0.011,0.033)	0.020 (0.005,0.037)	−0.829	0.470 (0.407)
		Third month	0.026 (0.005,0.044)	0.005 (0.000,0.019)	−2.015	0.044 * (0.073)
		Z	−0.341	−2.312
		p	0.733 (0.308)	0.021 * (0.020)
	Lactobacillus	Baseline	0.007 (0.003,0.049)	0.005 (0.002,0.012)	−1.420	0.156 (0.223)
		Third month	0.007 (0.000,0.068)	0.000 (0.000,0.047)	−1.666	0.096 (0.245)
		Z	−1.150	−0.973
		p(adj. val.)	0.130 (0.073)	0.330 (0.167)
Bacteroidetes		Baseline	0.249 (0.120,0.323)	0.110 (0.072,0.180)	−2.793	<0.01 ** (0.011)
		Third month	0.151 (0.061,0.256)	0.108 (0.042,0.236)	−0.591	0.555 (0.415)
		Z	−2.451	−1.004
		p(adj. val.)	0.014 * (0.016)	0.361 (0.188)
	Bacteroides	Baseline	0.144 (0.057,0.256)	0.047 (0.023,0.119)	−3.244	<0.01 ** (<0.01)
		Third month	0.064 (0.027,0.106)	0.057 (0.009,0.085)	−0.978	0.328 (0.364)
		Z	−2.354	−0.335
		p(adj. val.)	0.019 * (0.013)	0.735 (0.308)

Z-value and p-value for comparisons by Mann–Whitney U or Wilcoxon for between or within group differences at the baseline and third month, the result presented as M (P25,P75). * p < 0.05; ** p < 0.01; M(P25,P50): median (25th and 75th percentile). P value (adj. val.), FDR < 0.2 was considered as significant.