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. 2020 Sep 27;9(10):3120. doi: 10.3390/jcm9103120

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Mechanism of action of melflufen. Melflufen readily diffuses through the cell membrane into the myeloma cell, where it is cleaved by aminopeptidases to release the alkylating payload that are entrapped. ^a Aminopeptidases are proteolytic enzymes expressed in cancer cells, including multiple myeloma cells. pFPhe, p-L fluoro-phenylalanine ethyl ester. From Oriol A, et al. Expert Opin Invest Drugs. 2020 Sep 14 [online ahead of print] doi: 10.1080/13543784.2020.1808884. Copyright © 2020 Taylor & Francis. Reprinted with permission from Taylor & Francis Ltd.