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. 2020 Sep 27;9(10):3120. doi: 10.3390/jcm9103120

Table 1.

Comparison between melflufen and the known alkylator melphalan [30,33,40].

Characteristic Melflufen Melphalan
Chemical structure graphic file with name jcm-09-03120-i001.jpg graphic file with name jcm-09-03120-i002.jpg
Peak intracellular melphalan concentration * Relative concentration: ≈80 (achieved after 15 min exposure) Relative concentration: ≈4 (achieved after 60 min exposure)
Mean IC50, μM † 0.05 1.5
Lipophilicity (LogP) ‡ 4.0 −0.97

* Evaluated in U1810 cells after up to 120 min of exposure with 10 μM melflufen and 10 μM melphalan. † Mean IC50 value was obtained from 15 primary cultures from patients with hematologic malignancies. ‡ The partition coefficient, LogP, is a measure of the propensity for a compound to dissolve in lipids and water. A positive value indicates a higher concentration in the lipid phase, whereas a negative value indicates a higher concentration in water.