Table 1.

Knockdown of autophagy genes and effects on bone remodeling activity.

Knock Downed Gene	Effect on Bone Cells
ATG5	Reduction of osteoblast and osteoclast differentiation [53]
ATG7	Reduction of osteoblast differentiation [54] Impaired cathepsin K secretion by osteoclast and impaired bone resorption [55] Osteocyte-mediated induction of aging-like phenotype [54,56]
Beclin	Reduction of mineralization activity by osteoblasts [57]
LC3	Impairment of bone resorption [58]