Table 2.

ROC analysis of different cytokines for the diagnosis of CD in control and NCGS groups

Group	Cytokines	Cut-off point (ng/ml)	AUC	Sensitivity	Specificity	PPV	NPV
CD vs. control	IFN-γ	1.50	0.55	73.60	41.30	73.20	33.90
	IL-1	2.34	0.45	36.40	78.30	80.00	33.96
	IL-15	68.79	0.68	82.70	56.50	81.98	57.78
	IL-6	5.80	0.51	76.40	32.60	73.04	36.59
	IL-8	26.66	0.60	80.00	45.70	77.88	48.84
	Total*	0.29	0.66	44.5	87.0	61.90	19.44
CD vs. NCGS	IFN-γ	1.50	0.70	73.60	66.70	94.19	25.64
	IL-1	1.07	0.71	95.45	40.30	89.43	25.50
	IL-15	86.17	0.64	57.30	73.30	94.03	18.97
	IL-6	6.25	0.59	49.10	80.00	94.74	17.65
	IL-8	29.51	0.78	74.50	73.36	95.35	30.21
	Total	0.13	0.75	70.2	60.0	76.60	11.22

PPV, positive predictive value; NPV, negative predictive value