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Gut microbiota, gut permeability and lipopolysaccharides (LPS) absorption. Paracellular permeability of the intestinal epithelium is affected by zonulin production of the basal lamina, dietary factors and gut microbiota that produce zone occludens toxin. Increased permeability leads to more LPS translocation to the systemic circulation, which has a pro-inflammatory effect and further increases gut permeability.
