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Enterohepatic cycle of bile acids. Hepatic conversion of cholesterol results in primary bile acids, that are excreted postprandially by the gallbladder. Active reuptake takes place in the terminal ileum. In the colon, primary bile acids are converted to secondary bile acids by gut microbiota, and passively reabsorbed. Farnesoid X receptor (FXR) and Takeda G-protein coupled receptor 5 (TGR5) have a preference for secondary bile acids.
