Figure 1.

Sequence alignment of AlboD7 and AeD7 salivary proteins. Comparison of AlboD7 and AeD7 long form salivary proteins: AlboD7L1 (GenBank: AAV90665.1), AeD7L2 (GenBank: AAL16049), AlboD7L2 (GenBank: AAV90666.1), and AeD7L1 (GenBank: AAA29347). Sequences without a signal peptide were aligned with Clustal Omega and refined using the BoxShade server. Black background shading represents identical amino acids, while grey shading shows similar amino acids. The magenta boxes show the predicted amino acids involved in the U-46619, thromboxane A₂ analog; the cyan box indicates the Tyr-52 predicted to be involved in the TxA₂ binding, based on the solved crystal structure of the AnSt-D7L1 protein [37]; the yellow boxes reflect the amino acids involved in the norepinephrine binding according to the crystal structure obtained from AeD7L1 bound to norepinephrine [35].