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KD of selected RA9-mutant clones (RA9-mutant number #—as indicated), full-length antibody clones were measured by BLI against biotinylated SLea-PAA or biotinylated Lea-PAA, as a negative control.
| Antibody | Kon (1/Ms) | Koff (1/s) | KD (nM) | KD Native/ KD RA9-mutant # |
|---|---|---|---|---|
| Native | 5.4 × 104 | 2.3 × 10−3 | 42 | 1 |
| RA9-1 | 7 × 104 | 6.3 × 10−4 | 9 | 4.7 |
| RA9-15 | 1.2 × 104 | 2.1 × 10−3 | 18 | 2.3 |
| RA9-16 | 1.1 × 104 | 1.2 × 10−3 | 11 | 3.8 |
| RA9-23 | 1 × 104 | 1.2 × 10−3 | 12 | 3.5 |
| RA9-30 | 7.4 × 104 | 2.7 × 10−3 | 37 | 1.1 |
