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Perifocal Inflammation is a hypersensitivity reaction to tuberculin that surrounds recent, but not old, lesions of both primary tuberculosis (TB) and primary TB (PPTB). It consists of edema and interstitial lymphocytic inflammation. It is a major cause of toxemia and death of adults with acute TB. It is a toxic edema (delayed type hypersensitivity) that usually contains no acid fast organisms. It is typically associated with vasculitis (insert) (H&E stain 100×).
