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. 2020 Sep 24;12(10):2932. doi: 10.3390/nu12102932

Figure 2.

Figure 2

Rhubarb root extract blunts glucose intolerance, hepatic steatosis and liver inflammation (a) Plasmatic glucose (mg/dL) measured 6 h after a fasting period. (b) Plasma glucose profile (mg/dL) measured between 30min before and 120 min after glucose loading (n  = 8–10/group) and corresponding area under the curve. (c) Plasma insulin levels (µg l−1) at 30 min before and 15 min after glucose loading. (d) Insulin resistance index determined by multiplying the AUC of blood glucose by the AUC of insulin. (e) Hepatic lipid content (µg lipids/mg liver) and hepatic triglycerides (nmol/mg liver) measured by Folch. (f) Hepatic cholesterol (nmol/mg liver) measured by Folch. (g) Thiobarbituric acid reactive substances (TBARS) in the liver. (h) Hepatic inflammation markers measured using Bioplex. White, CTRL fed mice; Black, HFHS fed mice and Blue, HFHS fed mice supplemented with rhubarb. Data represent mean ± SEM. * p ≤ 0.05, ** p ≤ 0.01, *** p ≤ 0.005. OGTT, Oral glucose tolerance test; AUC, Area under the curve; IR Index, Insulin resistance index; TBARS, Thiobarbituric acid reactive substances; RANTES, Regulated upon Activation, Normal T Cell Expressed and Presumably Secreted; TNF-α, Tumor necrosis factor-alpha; IL-6, Interleukin-6; IFN-γ, Interferon-gamma.