Table 5.
Detailed information of patients with distant metastases.
| No. | Age at Dx | Sex | Sporadic/Hereditary | Preoperative Serum Calcitonin (pg/mL) | Primary Tumor Size (cm) | Number of LNMs | Central LNM | Ipsilateral Lateral LNM | Contralateral Lateral LNM | N Stage | Site of the Initial Distant Metastasis |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 21 | M | Sporadic | 109 | 4.5 | 14 | Positive | Positive | Negative | N1b | Lung |
| 2 † | 47 | M | Sporadic | 543 | 1.5 | 26 | Positive | Positive | Negative | N1b | Lung |
| 3 | 39 | F | Sporadic | 1150 | 0.9 | 11 | Positive | Positive | Positive | N1b | Lung |
| 4 | 43 | M | Sporadic | 6012 | 2.8 | 38 | Positive | Positive | Negative | N1b | Lung |
| 5 | 63 | M | Sporadic | 7488 | 7.0 | 5 | Negative | Positive | Negative | N1b | Mediastinal soft tissue |
| 6 | 26 | F | Sporadic | 8060 | 4.1 | 26 | Positive | Positive | Positive | N1b | Liver |
| 7 | 55 | M | Sporadic | 17,450 | 2.6 | 14 | Positive | Positive | Negative | N1b | Lung, liver |
| 8 | 24 | F | Sporadic | 97,500 | 8.0 | 10 | Positive | Positive | Positive | N1b | Lung, bone |
No. = patient number; Dx = diagnosis; LNM = lymph node metastasis. † This patient did not harbor a germline RET gene alteration in his blood sample analysis, which is routinely performed in this hospital. Upon progression, his tumor specimen was subjected to a screening test for somatic RET gene alterations, and he has been enrolled in a clinical trial for RET-positive solid tumors since November 2019.