Table 6.

Likelihood ratios for preoperative serum calcitonin levels in diagnosing lymph node metastasis and distant metastasis.

Calcitonin Cut-Off (pg/mL)	N with Central LNM	N without Central LNM	Positive LR	Negative LR	N with IpsilateralLateral LNM	N without Ipsilateral Lateral LNM	Positive LR	Negative LR
20	2	20	1.22 (1.10–1.36)	0.14 (0.03–0.56)	0	22	1.26 (1.14–1.38)	0
100	3	41	1.65 (1.38–1.96)	0.10 (0.03–0.31)	1	43	1.64 (1.40–1.91)	0.04 (0.01–0.29)
200	8	54	1.98 (1.57–2.50)	0.20 (0.10–0.40)	4	58	2.02 (1.63–2.50)	0.12 (0.05–0.32)
300	13	61	2.17 (1.65–2.86)	0.29 (0.17–0.49)	7	67	2.33 (1.81–3.02)	0.18 (0.09–0.37)
400	23	62	1.86 (1.37–2.51)	0.50 (0.35–0.73)	12	73	2.53 (1.89–3.40)	0.27 (0.16–0.45)
500	25	67	2.07 (1.47–2.89)	0.51 (0.36–0.72)	13	79	2.94 (2.10–4.12)	0.29 (0.17–0.47)
1000	40	76	1.98 (1.26–3.10)	0.72 (0.57–0.90)	27	89	3.21 (2.02–5.10)	0.53 (0.39–0.71)
2000	52	82	1.71 (0.95–3.05)	0.86 (0.73–1.02)	37	97	3.95 (2.09–7.48)	0.67 (0.54–0.82)
3000	59	88	1.78 (0.82–3.81)	0.91 (0.80–1.04)	47	100	3.27 (1.47–7.26)	0.82 (0.70–0.95)
5000	61	91	2.16 (0.87–5.25)	0.91 (0.82–1.02)	49	103	4.50 (1.70–12.10)	0.83 (0.72–0.95)
7000	64	92	1.82 (0.66–5.00)	0.95 (0.86–1.04)	51	105	6.32 (1.85–22.02)	0.85 (0.75–0.95)
10,000	68	94	1.37 (0.35–5.26)	0.98 (0.92–1.06)	56	106	5.11 (1.09–25.11)	0.92 (0.85–1.00)
Total	72	98			62	108
Calcitonin cut-off (pg/mL)	N with Contralateral Lateral LNM	N without Contralateral Lateral LNM	Positive LR	Negative LR	N with Distant Metastasis	N without Distant Metastasis	Positive LR	Negative LR
20	0	22	1.16 (1.09–1.24)	0	0	22	1.16 (1.09–1.23)	0
100	0	44	1.40 (1.26–1.54)	0	0	44	1.37 (1.25–1.51)	0
200	0	62	1.66 (1.46–1.89)	0	1	61	1.40 (1.05–1.87)	0.33 (0.05–2.10)
300	0	74	1.90 (1.64–2.21)	0	1	73	1.59 (1.18–2.14)	0.28 (0.04–1.75)
400	2	83	1.83 (1.40–2.40)	0.27 (0.07–0.98)	1	84	1.82 (1.34–2.47)	0.24 (0.04–1.52)
500	2	90	2.03 (1.53–2.69)	0.25 (0.07–0.90)	1	91	2.00 (1.46–2.74)	0.22 (0.04–1.40)
1000	5	111	2.23 (1.40–3.54)	0.50 (0.25–1.02)	2	114	2.53 (1.59–4.03)	0.36 (0.11–1.19)
2000	7	127	2.69 (1.45–4.99)	0.61 (0.36–1.04)	3	131	3.27 (1.75–6.09)	0.46 (0.19–1.14)
3000	8	139	3.94 (1.85–8.35)	0.64 (0.41–1.01)	3	144	5.63 (2.82–11.23)	0.42 (0.17–1.03)
5000	8	144	5.57 (2.47–12.57)	0.62 (0.39–0.98)	3	149	7.81 (3.69–16.46)	0.41 (0.17–1.00)
7000	10	146	4.47 (1.60–12.39)	0.76 (0.55–1.07)	4	152	8.07 (3.24–20.26)	0.53 (0.27–1.07)
10,000	11	151	6.69 (1.78–25.10)	0.81 (0.62–1.07)	6	156	6.76 (1.61–28.33)	0.78 (0.52–1.16)
Total	14	156			8	162

N = number of patients; LNM = lymph node metastasis; LR = likelihood ratio; Negative LR below 0.2 and Positive LR above 5 were marked in bolds number.