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. 2020 Sep 25;12(10):1079. doi: 10.3390/v12101079

Table 2.

Summary of mechanisms underlying transcriptional regulation and latency of deltaretroviruses.

No. Regulatory mechanism
1 Epigenetic mechanisms
2 Transcription factors acting as activators
3 Tissue-specific expression of the proviral genome
4 Viral transactivator Tax is critical for viral infectivity and pathogenesis
5 Transcription factors acting as repressors
6 Glucocorticoid hormones can modulate the induction of BLV expression and pathology
7 LTR sequence variation plays an important role in retroviral replication and modulation of viral latency
8 Host and viral ncRNA play important role in regulation of retrovirus transcription