Table 4.

Available human and animal cell lines used for in vitro biotransformation and bioavailability of drugs and xenobiotics.

Cell line	Origin	Transporters, Enzymes and Other Relevant Proteins	References
Caco-2	Human colon adenocarcinoma	CYP1A1, 1A2 GST, UGT, SULT, NAT P-gp, MRP-2, BCRP	[76,77,78]
HT-29	Human colon adenocarcinoma	CYP2C8, CYP2J2, CYP3A4 GST, UGT MRP1, MRP2, p-gp, BCRP	[79,80,81]
TC-7	Caco-2 subclones	Similar to Caco-2	[82]
T84	Human colonic carcinoma	P-gp, MRP2, MRP3	[83,84]
H4	Human small foetal intestine	CYP3A4	[85]
IPEC-J2	Neonatal pig small intestine	CYP1A1, 1A2, 3A29 P-gp, MRP1, BCRP	[86,87]