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. 2020 Oct 8;9(10):2252. doi: 10.3390/cells9102252

Figure A1.

Figure A1

Shortened survival and reduced body weight in female Ldlr−/−LmnaG609G/G609G and Ldlr−/−LmnaG609G/+ mice. (a) Kaplan–Meier survival curves of Ldlr−/−Lmna+/+ mice (n = 7), Ldlr−/−LmnaG609G/+ mice (n = 7), and Ldlr−/−LmnaG609G/G609G mice (n = 6) fed normal chow. (b) Body weight curves for Ldlr−/−Lmna+/+ mice (n = 7), Ldlr−/−LmnaG609G/+ mice (n = 7), and Ldlr−/−LmnaG609G/G609G mice (n = 6) fed normal chow. Body weight is shown until death for Ldlr−/−LmnaG609G/+ and Ldlr−/−LmnaG609G/G609G mice, and until 80 weeks of age for Ldlr−/−Lmna+/+ mice. Data are presented as mean ± SEM in (b). Statistical analysis was performed by log-rank test in (a) and by mixed effects model with the Geisser–Greenhouse correction in (b). ***, p < 0.001.