Table 5.
Inflammation, endothelial function, and genotoxicity.
| Outcome Measures | Controls | PWH: 0 Weeks p-Value: HIV 0 w vs. Con |
PWH: 12 Weeks p-Value: HIV 0 w vs. HIV 12 w |
PWH: 20 Weeks p-Value: HIV 12 w vs. HIV 20 w |
|---|---|---|---|---|
| Plasma high-sensitivity IL-6 (pg/mL) | 0.8 ± 0.2 | 4.9 ± 1.0 p = 0.000 |
1.7 ± 0.7 p = 0.000 |
2.5 ± 1.0 p = 0.003 |
| Plasma TNFα (pg/mL) | 33.8 ± 10.5 | 89.9 ± 15.1 p = 0.000 |
59.1 ± 8.0 p = 0.000 |
64.5 ± 7.4 p = 0.006 |
| Plasma high-sensitivity C-Reactive Protein (ng/mL) |
0.4 ± 0.0 | 2.2 ± 0.3 p = 0.000 |
1.1 ± 0.3 p = 0.000 |
1.3 ± 0.3 p = 0.034 |
| Plasma sICAM1 (ng/mL) |
364.9 ± 114.5 | 994.1 ± 222.8 p = 0.000 |
445.4 ± 99.9 p = 0.000 |
658.8 ± 104.8 p = 0.000 |
| Plasma sVCAM1 (ng/mL) |
627.1 ± 132.7 | 1643.9 ± 289.7 p = 0.000 |
976.5 ± 263.4 p = 0.000 |
1247.4 ± 245.1 p = 0.001 |
| Plasma E-Selectin (ng/mL) |
28.2 ± 7.6 | 62.8 ± 12.4 p = 0.000 |
41.1 ± 9.3 p = 0.000 |
52.1 ± 9.6 p = 0.000 |
| Plasma 8-OHdG (pg/mL) | 53.4 ± 4.8 | 182.0 ± 44.4 p = 0.000 |
54.9 ± 4.7 p = 0.000 |
115.3 ± 49.7 p = 0.01 |