Table 4.
Effects of vildagliptin and metformin on postprandial non-nutritive microvascular reactivity and vasomotion.
| TIME (min) | ||||||
|---|---|---|---|---|---|---|
| Group | Baseline | 30 | 60 | 120 | 180 | |
| Non-nutritive microflow | ||||||
| Mean Value (PU) | ||||||
| post-treatment | MET | 12[5.9–15.7] | 10.2[5.7–12.3] | 10.1[5.4–13.2] | 10[5.5–11] | 10.4[5.6–16] |
| post-treatment | VIL | 13.1[8.5–2] | 12.3[7.8–18.4] & | 12[7.5–18] & | 11.4[5.7–18] & | 10.9[5.6–17.7] |
| Mean Total (PU) | ||||||
| post-treatment | MET | 0.2[0.1–0.3] | 0.1[0.1–0.3] | 0.1[0.1–0.3] | 0.1[0.1–0.2] | 0.1[0.1–0.2] |
| post-treatment | VIL | 0.1[0.1–0.3] | 0.2[0.1–0.3] | 0.1[0.1–0.3] | 0.1[0.1–0.2] | 0.1[0.1–0.2] |
| Microvascular vasomotion | ||||||
| Total Frequency interval (Hz) | ||||||
| post-treatment | MET | 32.4[14.2–65.3] | 27.3[12.9–67.2] | 25.7[13.0–66.4] | 23.3[14.2–39.9] | 22.2[15.2–48.6] |
| post-treatment | VIL | 29.0[20.6–59.7] | 33.1[18.6–54.3] | 30.6[19.1–52.5] | 30.0[5.5–48.7] | 31.3[16.4–50.0] & |
| Endothelial (Hz) | ||||||
| post-treatment | MET | 4.2[2.2–7.7] | 3.7[2.1–6.4] | 3.9[2.5–8.8] | 4.1[2.5–7.0] | 4.4[1.8–8.6] |
| post-treatment | VIL | 4.7[3.1–7.6] | 3.9[2.2–10.9] | 5.3[2.0–9.0] | 4.9[2.6–8.9] | 4.8[2.4–7.4] |
| Sympathetic (Hz) | ||||||
| post-treatment | MET | 3.8[2.2–4.9] | 3.7[2.4–6.1] | 3.7[2.3–5.3] | 3.73[2.39–5.6] | 4.0[2.1–5.5] |
| post-treatment | VIL | 3.7[1.8–5.3] | 3.9[1.8–6.1] | 3.9[1.8–9.4] | 4.5[2.1–10.0] | 3.9[2.1–8.4] |
| Myogenic (Hz) | ||||||
| post-treatment | MET | 2.3[1.6–3.5] | 2.3[1.7–3.5] | 2.2[1.6–2.9] | 2.3[1.6–3.7] | 2.2[1.8–3.8] |
| post-treatment | VIL | 2.6[1.7–4.1] | 2.3[1.7–3.5] | 2.2[1.8–3.2] | 2.3[1.7–4.2] | 2.1[1.7–3.8] |
| Respiratory (Hz) | ||||||
| post-treatment | MET | 1.3[1.1–1.5] | 1.3[1.1–1.6] | 1.3[1.0–1.5] | 1.3[1.0–1.5] | 1.7[1.0–1.5] |
| post-treatment | VIL | 1.2[0.9–1.4] | 1.2[0.8–1.5] | 1.2[0.8–1.8] | 1.1[0.1–1.5] | 1.2[0.9–1.5] |
| Cardiogenic (Hz) | ||||||
| post-treatment | MET | 0.7[0.5–0.8] | 0.7[0.6–0.8] | 0.7[0.6–0.8] | 0.7[0.6–0.8] | 0.7[0.6–0.8] |
| post-treatment | VIL | 0.7[0.6–0.8] | 0.7[0.6–0.8] | 0.7[0.5–1.0] | 0.7[0.5–0.8] | 0.7[0.5–0.8] |
Data are expressed as medians [1st–3rd tertiles]. & Unpaired comparisons: & p < 0.05; PU–Perfusion units; Hz–Hertz; MET–Metformin group; VIL–Vildagliptin group.