Table A2.
Spearman coefficients of correlation in MS subjects between post-tilt cardiovascular and autonomic parameters, age, disease duration and EDSS score.
| Age | EDSS | Disease Duration | HR | sBP | dBP | mBP | Delta HR | Delta sBP | Delta dBP | Delta mBP | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Delta HR (1/min) | −0.35 * | −0.15 | −0.26 | −0.04 | −0.15 | −0.27 | −0.23 | 1.00 | 0.08 | 0.19 | 0.07 |
| Delta sBP (mmHg) | −0.04 | −0.07 | −0.03 | −0.18 | −0.13 | −0.15 | −0.14 | 0.08 | 1.00 | 0.84 *** | 0.90 *** |
| Delta dBP (mmHg) | −0.26 | −0.20 | −0.13 | −0.20 | 0.02 | −0.13 | −0.08 | 0.19 | 0.84 *** | 1.00 | 0.89 *** |
| Delta mBP (mmHg) | −0.13 | −0.13 | 0.01 | −0.23 | −0.12 | −0.18 | −0.14 | 0.07 | 0.90 *** | 0.89 *** | 1.00 |
| Delta LFnu-RRI (ms2) | −0.45 *** | −0.22 | −0.17 | −0.14 | 0.08 | −0.08 | −0.01 | 0.41 ** | −0.04 | 0.04 | −0.09 |
| Delta HFnu-RRI (ms2) | 0.45 ** | 0.22 | 0.17 | 0.14 | −0.08 | 0.08 | 0.01 | −0.41 ** | 0.04 | −0.04 | 0.09 |
| Delta LF-RRI (ms2) | 0.07 | 0.12 | −0.04 | 0.46 *** | −0.04 | 0.03 | 0.03 | −0.08 | 0.11 | −0.08 | −0.05 |
| Delta HF-RRI (ms2) | 0.38 * | 0.26 | 0.20 | 0.45 *** | −0.08 | 0.10 | 0.04 | −0.31 * | 0.10 | −0.07 | 0.06 |
| Delta PSD-RRI (ms2) | 0.20 | 0.16 | 0.09 | 0.52 *** | −0.07 | 0.04 | 0.00 | −0.19 | 0.07 | −0.07 | −0.05 |
| Delta LF/HF-RRI [1] | −0.32 * | −0.12 | −0.03 | 0.11 | 0.16 | −0.02 | 0.05 | 0.34 * | −0.07 | 0.08 | −0.06 |
| Delta LF/HF [1] | −0.31 * | −0.13 | −0.08 | 0.18 | 0.16 | −0.04 | 0.05 | 0.39 ** | −0.07 | 0.13 | −0.04 |
| Delta LFnu-dBP (%) | −0.23 | −0.11 | −0.08 | 0.11 | −0.09 | −0.20 | −0.13 | 0.30 * | 0.11 | 0.18 | 0.16 |
| Delta HFnu-dBP (%) | 0.31 * | 0.23 | 0.10 | 0.26 | −0.21 | −0.11 | −0.15 | 0.07 | −0.09 | −0.20 | −0.16 |
| Delta LF-dBP (%) | −0.10 | −0.03 | 0.05 | 0.07 | 0.21 | 0.04 | 0.12 | −0.14 | 0.12 | 0.18 | 0.22 |
| Delta HF-dBP (%) | 0.25 | 0.34 * | 0.10 | 0.35 * | 0.08 | 0.10 | 0.11 | −0.18 | −0.10 | −0.17 | −0.10 |
| PSD-dBP (mmHg2) | 0.03 | 0.22 | 0.17 | 0.21 | 0.22 | 0.21 | 0.21 | −0.35 * | −0.09 | −0.07 | −0.05 |
| Delta LF/HF-dBP | −0.23 | −0.22 | 0.01 | −0.19 | 0.12 | 0.02 | 0.07 | −0.04 | 0.13 | 0.29 ** | 0.26 |
| Delta LF/HF | −0.31 * | −0.13 | −0.08 | 0.18 | 0.16 | −0.04 | 0.05 | 0.39 ** | −0.07 | 0.13 | −0.04 |
| Delta LFnu-sBP (%) | −0.32 * | −0.14 | −0.17 | 0.07 | 0.13 | −0.07 | 0.04 | 0.27 | 0.26 | 0.41 ** | 0.30 * |
| Delta HFnu-sBP (%) | 0.12 | 0.17 | −0.06 | 0.26 | −0.15 | −0.10 | −0.15 | 0.31 * | −0.03 | −0.04 | −0.09 |
| Delta LF-sBP (%) | −0.15 | −0.12 | −0.10 | 0.00 | 0.16 | −0.04 | 0.06 | −0.03 | 0.21 | 0.26 | 0.25 |
| Delta HF-sBP (%) | 0.18 | 0.23 | 0.04 | 0.25 | 0.04 | 0.04 | 0.04 | 0.04 | −0.07 | −0.10 | −0.06 |
| Delta PSD-sBP (mmHg2) | −0.05 | 0.08 | 0.05 | 0.18 | 0.14 | 0.13 | 0.13 | −0.25 | −0.13 | −0.12 | −0.05 |
| Delta LF/HF-sBP [1] | −0.25 | −0.30 * | −0.08 | −0.20 | 0.09 | −0.05 | 0.03 | −0.09 | 0.13 | 0.21 | 0.20 |
| Delta LF/HF [1] | −0.27 | −0.12 | −0.06 | 0.15 | 0.20 | −0.01 | 0.09 | 0.33 * | −0.02 | 0.16 | −0.01 |
Expanded Disability Status Scale (EDSS); HR, heart rate; sBP, systolic blood pressure; dBP, diastolic blood pressure; mBP, mean blood pressure; delta, change baseline-tilt delta; delta HR, delta heart rate; delta sBP, delta systolic blood pressure; delta dBP, delta diastolic blood pressure; delta mBP, delta mean blood pressure; delta LFnu-RRI, delta low-frequency R-R interval in normalized units; delta HFnu-RRI, delta high frequency R-R interval in normalized units; delta LF-RRI, delta low-frequency R-R interval; delta HF-RRI, delta high-frequency R-R interval; delta PSD-RRI, delta power spectral density R-R interval; delta LF/HF, delta ratio between low and high band for heart rate and blood pressure variability; delta LF/HF-RRI, delta ratio between low and high band for heart rate variability; delta LFnu-dBP, delta low frequency of diastolic blood pressure variability in normalized units; delta HFnu-dBP, delta high frequency of diastolic blood pressure variability in normalized units; delta LF-dBP, delta low frequency of diastolic blood pressure variability; delta HF-dBP, delta high frequency of diastolic blood pressure variability; delta PSD-dBP, delta power spectral density of diastolic blood pressure variability; LF/HF-dBP, ratio between low and high band for diastolic blood pressure variability; delta LFnu-sBP, delta low frequency of systolic blood pressure variability in normalized units; delta HFnu-dBP, delta high frequency of systolic blood pressure variability in normalized units; delta LF-sBP, delta low frequency of systolic blood pressure variability; delta HF-sBP, delta high frequency of systolic blood pressure variability; delta PSD-sBP, delta power spectral density of systolic blood pressure variability; delta LF/HF-sBP, delta ratio between low and high band for systolic blood pressure variability; delta BRS, delta baroreflex sensitivity; delta total BEI, delta baroreflex effectiveness; nu, normalized values; statistically significant differences are indicated with * p < 0.05, ** p < 0.01, *** p < 0.001.