Figure 1.

Genetic heterogeneity in the metastatic colorectal cancer (CRC) cohort. The total number of mutations (top panel), and copy number events, with percentage genome altered (bottom panel) detected in all tumour regions sampled per patient (n = 30), with clinical details and markers, such as age, primary site, metastatic site, onset of metastasis, treatment status, number of sequenced regions, and genome doubling. The percentage of variants shared between primary and metastasis, specific to primary, or specific to metastasis have been indicated in the middle panel. “P” refers to primary CRC tumour and “M”, refers to metastatic lesion. The treatment status of the primary tumour of patient 112-107, marked by an asterisk (*), was not available.