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. 2020 Oct 13;12(10):2960. doi: 10.3390/cancers12102960

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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An immune-related gene signature, based on GASC study, could predict GBM prognosis. The prognostic value of CCL2, CXCL2, IL8, SPP1 and TGFB1 was assessed independently in the TCGA-GBM RNA-seq dataset and was represented by Kaplan-Meier plots. Both the (A) Overall Survival (OS, left panel) and the (B) Disease-Free Survival (DFS, right panel) were evaluated. Afterwards, the analysis was repeated considering the five-genes signature (median expression). Patients were stratified based on the optimal cut-point and data were censored at 24 months for OS and at 12 months for DFS.