Table 1.
Summary of fumaric acid esters either approved for human use, previously tested or currently examined in human/animal trials.
| Status | Compound | Disease | Phase of Trial |
|---|---|---|---|
| Approved for Human Use | Dimethyl Fumarate | Multiple Sclerosis | Approved |
| Psoriasis | Approved | ||
| Diroximel Fumarate | Multiple Sclerosis | Approved | |
| Monomethyl Fumarate | Multiple Sclerosis | Approved | |
| Human Trials | Dimethyl Fumarate | Amyotrophic Lateral Sclerosis | Phase II |
| Cutaneous T Cell Lymphoma | Phase II | ||
| Glioblastoma Multiforme | Phase II | ||
| Obstructive Sleep Apnoea | Phase II | ||
| Rheumatoid Arthritis | Phase II | ||
| Pre-clinical Animal Trials | Dimethyl Fumarate | Breast Cancer | Pre-clinical |
| Colitis | |||
| Melanoma | |||
| Pancreatitis | |||
| Parkinson’s Disease | |||
| Sickle Cell Disease | |||
| Monomethyl Fumarate | Gastric Ulcer | ||
| Sickle Cell Retinopathy |