Table 5.
Anticoagulant activity measurements of FucCS reported from sea cucumbers in recent years.
| Sea Cucumber Spp. | aPTT | TT | PT | Anti FXase | Anti FIIa/Plasma | Anti FXa/AT | Anti FXa/HCII | Anti FIIa/AT | Anti FIIa/HCII | Mol. Wt | Ref. |
|---|---|---|---|---|---|---|---|---|---|---|---|
| μg/ml | IC 50 (ng/mL) | kDa | |||||||||
| Apostichopus japonicas | 3.06 | - | - | 9.20 | - | - | - | - | - | 76.4 | [66] |
| Bohadschia argus | 4.13 | - | 1280 | 14.83 | - | 3341 | - | 530.8 | - | 70.3 | [73] |
| Cucumaria frondosa | - | - | - | - | - | 1000 | - | 500 | 1000 | 58 | [72] |
| Cucumaria japonica | 2.5 | - | - | - | - | - | - | - | - | - | [75] |
| Holothuria coluber | 4.94 | 10.32 | 1280 | 14.73 | - | - | - | - | - | 49.48 | [64] |
| Holothuria coluber | 3.31 | 7.68 | 26.4 | - | 10000 | - | 1260 | - | 54.9 | [65] | |
| Holothuria fuscopunctata | 3.45 | 6.46 | 1280 | 41.9 | - | 10000 | - | 448 | 589 | 42.6 | [76] |
| Holothuria lentiginosa | 30 IU/mg | - | - | - | 10.2 | 5.5 | - | 0.7 | - | 50.8 | [77] |
| Holothuria mexicana | 100 | 150 | - | - | - | 1000 | - | 100 | - | - | [67] |
| Holothuria pollii | 220 IU/mg | - | - | - | - | - | - | 125 | 35 | 45.8 | [70] |
| Holothuria scabra | 20 | 60 | - | - | - | - | - | - | - | 69.1 | [74] |
| Massinium magnum | 2.8 | 6 | - | - | - | - | - | - | - | 27 | [71] |
| Patallus mollis | 3.5 | 10.7 | - | 13.7 | - | - | - | - | - | 60.3 | [63] |
| Pearsonothuriagraffei | 20.9 | 9.84 | - | 330 | - | 5490 | - | 5080 | - | 73 | [78] |
| Thelenota ananas | - | - | - | - | - | 1000 | - | 500 | 1000 | 63 | [72] |
PT-Prothrombin time.