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. 2020 Oct 13;17(20):7457. doi: 10.3390/ijerph17207457

Table 6.

Summary of studies analyzing treatment methods and time to recovery.

Study Design
Level of Evidence (NHMRC)
Participants Methodology Results (p <0.05)
Loudon and Dolphino, 2010 [28] Case series
IV
23 runners with MTSS (12♂/11♀)
  • Age: 28.1 ± 5.9

Initial measurements:
▪ Alignment: ND test and talocrural dorsiflexion ROM
▪ Pain (NPRS)
Treatment (3 weeks):
▪ Off-the-shelf BFO
▪ Home stretching program
Follow-up:
▪ GRC questionnaire by email (Post 7 and 21 days)
▪ ↓ Duration of the symptoms: 44% ♀and 83% ♂
▪ ↓ Pain level in the successful group
▪ Improvement in GRC in the successful group (post 21 days)
Mulvad et al., 2018 [29] Cohort
III-2
112 injured runners (30♂/82♀)
  • Age: 41.4(21–63)

▪18 runners with MTSS (16%)
▪ Clinical examinations ▪ MTSS had the longest time to recovery (70 days)
Naderi et al., 2019 [26] Case–control
III-2
100 runners (100♂)
▪ 50 runners with MTSS
  • Age: 21.9 ± 2.4

▪ 50 healthy runners
  • Age: 21.1 ± 2.5

▪ Arch-support full-length footorthoses in the shoes
▪ Pain measurement (algometry, VAS)
▪ Foot postures (FPI-6)
▪ Dynamic pressure distribution during running (stance phase)
After using arch-support foot- orthosesin MTSS runners:
▪ ↓ Total contact time
▪ ↓ Absolute impulse in the midfoot region and ↑peak pressure and absolute impulse underneath the M5 region
▪ Pressure distribution was laterally at FFF and HO
▪ Pressure displacement was shifted from lateral to medial during FFCP and from medial to lateral during FFPOP
▪ The X-component of the COP was more medially at FFF and was displaced to lateral side during FFPOP
▪ The X-component of the COP was laterally at FFF and the lateral COP displacement ↓during FFPOP
Newman et al., 2017 [23] Randomized controlled trial
II
24 runners with MTSS
▪ Experimental group: 12 (5♂/7♀)
  • Age: 34 ± 11

▪ Control group: 12 (5♂/7♀)
  • Age: 36 ± 9

Treatment:
▪ Experimental group: standard dose shockwave therapy (total = 1450 mJ/mm2)
▪ Control group: sham dose shockwave therapy (total = 70 mJ/mm2)Measurements:
▪ Pain: pressure algometry and during running (NRS)
▪ Self GROC questionnaire
Follow-up:
10 weeks
▪ No significant differences between groups
Nielsen et al., 2014 [31] Cohort
III-2
254 injured runners
▪ 38 runners with MTSS (15%), (18♂/20♀)
▪ Clinical examinations
▪ Prospective follow-up to determine time to recovery
▪ Mean time to recovery of 72 days

BFO: Basic Foot Orthotic; COP: Center of Pressure; FFCP: Forefoot Contact Phase; FFF: Forefoot Flat; FFPOP: Forefoot Push-Off Phase; FPI-6: Foot Posture Index; GRC: Global Rating of Change; GROC: Global Rating of Change; mJ: millijoules; NHMRC: National Health and Medical Research Council; NPRS: Numerical Pain Rating Scale; MTSS: Medial Tibial Stress Syndrome; M5: 5th metatarsal; ND: navicular drop; NRS: Numerical Rating Scale; ROM: Range of Motion; VAS: Visual Analog Scale. ♂: man; ♀: woman.