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. 2020 Oct 14;12(10):2977. doi: 10.3390/cancers12102977

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Immunohistochemical staining with CD31 (5×) shows an increase in neoformed blood vessels at the lower third of the mucosa with an edematous area near the muscularis mucosae. This area, which is not observed in the control sections, shows neoangiogenesis and inflammatory cells. Additionally, a dissolution of the lamina of the muscularis mucosae by edema and inflammation is visible. The immunostaining with caldesmone (5×) tends to overlap with CD31 and seems to more clearly define the edematous area with neoangiogenesis between the terminal portion of the gastric glands and the muscular bundles of the muscularis mucosae. The two immunocolorings are relatively overlapping and confirm the neoangiogenesis highlighted in H&E.