Table 2.
PK parameters attained and targeted values (represented by parenthesis) in the PK/PD model.
| Parameter | DAL | VAN | DAP | CFZ |
|---|---|---|---|---|
| fCmax (mg/L) | 30.1 ± 0.018 (30.1) | 34.9 ± 0.76 (36.0) | 13.95 ± 0.04 (14.1) | 27.55 ± 0.91 (26.0) |
| T1/2 (h) | 184 ± 0.01 (187.40) | 6.6 ± 0.03 (6.00) | 7.6 ± 0.07 (8.00) | 2.4 ± 0.04 (2.3) |
| AUC (mg × h/mL) or T > MIC (h) | 7255± 0.03 | 324. 66 ± 1.3 | 192.6 ± 0.09 | 0.00 |
| fAUC/MIC | 58,040 (D712) 50,040 (6913) |
81 (D712) 40 (6913) |
96 (D712) 49 (6913) |
234,082 (DAL+CFZ D712); 646 (VAN+CFZ; D712); 1541( DAP+CFZ; D712); 234,082 (DAL+CFZ; 6913) 323 (VAN+CFZ; 6913); 385 (DAP+CFZ; 6913) |
Represented in Table 2 are the PK parameters attained in the in-vitro one-compartment models.