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P-CTX-1 sensitizes C-type sensory fibers to cold in a Nav1.8- and TRPA1-dependent manner. Ongoing activity induced by P-CTX-1 (0.5 nM) in single C-fibers recorded from murine skin-saphenous nerve preparations from wild-type (wt) mice (a) and TRPA1-deficient mice (b). Residual cumulative action potentials induced in 5 min in single C-fibers from Nav1.8-deficient mice (c) compared with wt mice. Reprinted from [111] with editor permission.
