Figure 2.

Schematic overview of the cell cycle and cell cycle targeting inhibitors in MCL and other B cell lymphomas. Progression of the cell cycle is facilitated by specific interaction and activation of CDKs with cyclins to allow cell cycle progression. Listed are cell cycle inhibitors currently under investigation for the treatment of MCL and B cell lymphomas, in addition to upstream targeted inhibitors against DDR proteins. Abbreviations: CDK: cyclin-dependent kinases, MCL: mantle cell lymphoma, DDR: DNA damage response. Created with BioRender.com.