Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Oct 14;9(10):2287. doi: 10.3390/cells9102287

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Schematic depiction of potential synergistic effects of DNA repair inhibition, cell cycle inhibition, and immune checkpoint blockade in MCL. Schematic figure showing selected features of treatment naïve MCL resulting in the proliferation of malignant cells (panel A) in contrast to potentially synergistic effects of the currently available treatments targeting cell cycle inhibition in combination with ICB (panel B). Dashed lines indicate a lower than normal transcription/function. Targetable cell cycle machinery and respective interventions are highlighted in bold and by lightning symbols. Abbreviations: MCL: mantle cell lymphoma, TME: tumor microenvironment, ICB: immune checkpoint blockade, SASP: senescence-associated secretory phenotype, STING: stimulator of interferon genes, PARPi: PARP inhibition. Created with BioRender.com.