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. 2020 Oct 14;10(10):820. doi: 10.3390/diagnostics10100820

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Consolidated standards of reporting trials (CONSORT) flow diagram of the study. 125 subjects were screened and one subject was excluded due to lack of teeth. Finally 124 subjects were included in this study and allocated into the five groups of periodontal status including healthy, periodontitis stage I, II, III, and IV. Three subjects were excluded in the analysis due to failure in enzyme-linked immunosorbent assay (ELISA) dectection. A total 121 subjects were included in the final analysis.