Table 6.
Most representative antimicrobial PEI-Ds developed in the years 2010–2020 and antibacterial activity of the most effective ones among the series synthetized.
| Dendrimer Structure | Proposed Mechanism | HC50 (μg/mL) | Cytotoxicity IC50 (μg/mL) | Target Bacteria | Activity (μg/mL) |
|---|---|---|---|---|---|
| PEI-D 4[N[(Ts)(2-(methyl)-5-aryl-1,3,4 oxadiazole)]] [55] |
OM/CM damage OM/CM disruption by PEI fraction Electron donating action of heterocycle groups |
N.D. | N.D. |
B. subtilis S. aureus S. epidermidis E. coli X. campestris S. typhi P. aeruginosa |
MIC 12.5 12.4 12.5 12.5 12.5 5 12.5 |
| Unmodified b-PEI-D [56] |
OM/CM damage OM/CM disruption | >4000 | 27→4000 (1 h) 1 7–2305 (24 h) 1 |
E. coli S. aureus |
MIC 250 16 |
1 HEp-2 cells.