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. 2020 Oct 30;17:52. doi: 10.1186/s12970-020-00381-6

Table 1.

Characteristics of methods for assessing hydration

Hydration assessment/variable Hydrated upper limit Limitationsa Precision/reliability Cost Invasiveness Administrator skill required Time required
Stable isotope dilution N/A Expensive and time consuming 5 5 5 5 5
Neutron activation analysis N/A Expensive and time consuming 5 5 5 5 5
Haematocrit < 2% change Influenced by many confounding factors 3 3 3 3 2
Plasma/serum osmolality < 296 mmol/kg Expensive and invasive 4 4 4 4 2
Serum sodium concentration < 145 mEq/L Expensive and invasive 3 4 4 4 2
Hormonal variables N/A Expensive and undetermined validity/reliability 2 4 4 5 4
Urine specific gravity < 1.020 SG Many confounding factors 2 2 2 2 1
Urine osmolality < 700 mmol/kg Many confounding factors 2 3 2 3 2
Urine colour < 4 Many confounding factors 1 1 2 1 1
Saliva osmolality < 61 mmol/kg Questionable reliability 1 3 2 3 2
Tear osmolality < 310 mmol/kg Undetermined validity/reliability 3 3 2 3 2
Body mass < 2% change Many confounding factors and only works within limited time periods 4 1 1 1 1
Bioimpedance N/A Many confounding factors and questionable reliability 3 2 1 1 1
Vital signsa N/A Questionably validity/reliability 1 1 1 2 1
Sensation of thirst < 3 (scale of 1–9) Low sensitivity 1 1 1 1 1

Rating: 1 = lowest, 5 = highest. N/A = Clear cut-off has not been defined or do not apply. aSee the respective section for more details