Table 2.
Univariate analyses.
| Factor | Whole Series | |||
|---|---|---|---|---|
| Median RFS (CI 95%) |
p | Median OS (CI 95%) |
p | |
| Age: | 0.34 | 0.4 | ||
| - 0–60 - >60 |
26.5 (15.1–37.9) 31.7 (22.7–40.8) |
155 (NA) NR |
||
| Sex: | 0.61 | 0.62 | ||
| - Male - Female |
31.7 (24.6–38.8) 32.2 (4.5–59.8) |
155.9 (43.4–268.4) NR |
||
| Size: | 0.075 | 0.001 | ||
| - 0–10 - >10 |
32.2 (15.8–48.5) 27.3 (13.3–41.2) |
NR 73.4 (52.9–93.9) |
||
| Mitosis: | <0.001 | 0.13 | ||
| - 0–10 - >10 |
98.2 (0–218.6) 20 (13.5–26.5) |
NR 78 (37.7–118.2) |
||
| Critical mutation: | 0.64 | 0.8 | ||
| - Yes - No |
32.2 (16.2–48.1) 31.7 (21.4–42) |
NR 155.9 (36.7–275.2) |
||
| Tumor location: | 0.001 | 0.22 | ||
| - Small-intestine - Other |
33.4 (23.7–43.1) 13.4 (1.8–25) |
155.9 (NA) 77.6 (16.2–139.1) |
||
| let-7e expression *: | 0.012 | 0.32 | ||
| - <131.42 - >131.42 |
25 (18.2–31.8) 41.1 (18.2–64) |
90.2 (73.5–106.9) NR |
||
| miR550 expression *: | 0.136 | 0.55 | ||
| - <4063.67 - >4063.67 |
31.9 (21.1–42.6) 29.9 (20.7–39.2) |
155.9 (NA) NR |
||
| ACVR1B expression *: | 0.023 | 0.54 | ||
| - <0.000629 - >0.000629 |
43.6 (8.1–79.1) 28.9 (16.8–41.1) |
NR 117.3 (42.4–192.2) |
||
| CASP3 expression *: | 0.018 | 0.71 | ||
| - <0.000769 - >0.000769 |
39.5 (4–75.1) 26.5 (16.1–37) |
NR 155.9 (23.2–288.6) |
||
| COL3A1 expression *: | 0.012 | 0.037 | ||
| - <0.671380 - >0.671380 |
39.5 (26.9–52.2) 21.3 (7.5–35.2) |
NR 61.8 (23.9–99.7) |
||
| COL5A2 expression *: | 0.003 | 0.26 | ||
| - <0.014649 - >0.014649 |
35.5 (23.9–47.1) 14.1 (2.4–25.7) |
NR 81.1 (0–167.6) |
||
|
Median RFS
(CI 95%) |
p |
Median OS
(CI 95%) |
p | |
| Age: | 0.38 | 0.76 | ||
| - 0–60 - >60 |
32.4 (15.1–49.6) 35.5 (6.2–64.9) |
155 (NA) NR |
||
| Sex: | 0.5 | 0.75 | ||
| - Male - Female |
31.9 (24.3–39.6) 50.5 (9.8–91.1) |
155.9 (22.7–289.1) NR |
||
| Size: | 0.061 | 0.005 | ||
| - 0–10 - >10 |
36.9 (5.5–68.3) 28.9 (11.4–46.5) |
NR 73.4 (49.4–97.4) |
||
| Mitosis: | <0.001 | 0.14 | ||
| - 0–10 - >10 |
161.2 (2.7–319.6) 20.8 (15.4–26.1) |
NR 90.2 (36.3–144) |
||
| Critical mutation: | 0.22 | 0.63 | ||
| - Yes - No |
32.4 (10.8–53.9) 32.2 (16.2–48.1) |
NR 155.9 (36.7–275.2) |
||
| Tumor location: | ||||
| - Small-intestine - Other |
NA | NA | ||
| Let-7e expression *: | 0.003 | 0.38 | ||
| - <131.42 - >131.42 |
26.5 (20.6–32.5) 98.2 (0–225.1) |
90.3 (NA) NR |
||
| miR550 expression *: | 0.096 | 0.46 | ||
| - <4063.67 - >4063.67 |
35.5 (24.8–46.3) 32.2 (25.9–38.4) |
155.9 (NA) NR |
||
| ACVR1B expression *: | 0.028 | 0.57 | ||
| - <0.000629 - >0.000629 |
58.2 (0–128.6) 30 (22.7–37.2) |
NR 155.9 (50.7–261.1) |
||
| CASP3 expression *: | 0.008 | 0.34 | ||
| - <0.000769 - >0.000769 |
50.5 (0–106.7) 21.3 (7.6–35.1) |
NR 72.1 (0–150.7) |
||
| COL3A1 expression *: | 0.03 | 0.053 | ||
| - <0.671380 - >0.671380 |
39.5 (16.4–62.7) 25 (17.7–32.4) |
NR 61.8 (30.2–93.5) |
||
| COL5A2 expression *: | 0.002 | 0.17 | ||
| - <0.014649 - >0.014649 |
39.5 (26.6–52.4) 20.3 (8.4–32.1) |
NR 81.1 (0–168.9) |
||
* Optimal cutoff calculated using ROC curves.