Table 2.
Multivariable analysis assessing factors associated with disease recurrence and progression.
| Recurrence-Free Survival | Progression-Free Survival | |||||
|---|---|---|---|---|---|---|
| Variable | HR | 95% CI | p-Value | HR | 95% CI | p-Value |
| Age | 1.00 | 0.99–1.02 | 0.537 | 1.00 | 0.98–1.02 | 0.829 |
| Gender (female vs. male) | 1.07 | 0.67–1.46 | 0.971 | 0.97 | 0.47–1.58 | 0.627 |
| Smoking (never/any) | 1.02 | 0.74–1.39 | 0.917 | 1.01 | 0.60–1.57 | 0.902 |
| MP (yes/no) | 0.92 | 0.64–1.32 | 0.657 | 0.76 | 0.47–1.31 | 0.360 |
| Concomitant CIS (yes vs. no) | 1.35 | 0.95–1.92 | 0.094 | 1.33 | 0.79–2.22 | 0.278 |
| Size (≤3 cm vs. >3 cm) | 1.05 | 0.72–1.30 | 0.802 | 1.26 | 0.79–2.01 | 0.332 |
| Focality (solitary vs. multiple) | 0.99 | 0.73–1.33 | 0.932 | 1.35 | 0.86–2.13 | 0.194 |
| reTURB before/after | 0.93 | 0.67–1.27 | 0.667 | 0.96 | 0.60–1.53 | 0.864 |
| Residual tumour at reTURB yes/no | 2.62 | 1.94–3.54 | 0.000 | 3.01 | 1.90–4.77 | 0.000 |
The value of adjusted p < 0.05 was considered statistically significant (in bold); HR > 1 worse outcome for the option in bold, HR < 1 better outcome for the option in bold. Abbreviations: HR, hazard ratio; 95% CI, 95% confidence interval; CIS, carcinoma in situ; MP, muscularis propria.